The first RIR has run out only 10 weeks after IANA ran out.
http://www.apnic.net/community/ipv4-exhaustion/graphical-information shows one /8 left. That means they have effectively run out of IPv4 addresses as all ISPs can now get is a single last block of 1024, which for most will be next to useless. No more "normal" allocations.
This is pretty major. There are several steps to running out of IPv4 with the first being IANA in February. The next step is RIRs running out which has now started, and then after that LIRs (ISPs) running out.
APNIC running out means that no ISP can now get any normal allocations in the APNIC region. It means that ISPs will be forced to do nasty things with IPv4 NAT and make use of IPv6. We can expect the use of IPv6 only web sites and other services aimed initially at local markets where IPv6 users can access them.
When there are any significant places on the Internet that are IPv6 only (and not just www.loopsofzen.co.uk) we can finally address the head in the sand ISPs that say "We have plenty of IPv4s left". People like Virgin who seem to think it is not important for their customers to access IPv6 endpoints in the Internet will have to wake up!
It matters not how many of those old legacy IPv4 addresses you have if there are parts of the Internet you cannot reach using IPv4!!!